Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion

Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.

Thyroid cancer is the most common endocrine malignancy in the population, and the incidence of this cancer is increasing at a rapid rate. Although genetic analysis of papillary thyroid cancer (PTC) has identified mutations in a large percentage of patients, the genetic basis of follicular thyroid cancer (FTC) is less certain. Thyroid cancer, including both PTC and FTC, has been observed in pati...

Strain-Specific Aggressive Behavior of Male Mice Submitted to Different Husbandry Procedures

Brain aromatase activity and plasma testosterone levels are elevated in aggressive male mice during early ontogeny.

Testosterone (T) and estradiol (E2) are involved in intraspecific aggressive behavior. Both steroids exert their effects on behaviour via the hypothalamus and the amygdala (Am) of the central nervous system (CNS). In these brain areas T is converted to E2, by the enzyme aromatase. Both the levels of brain aromatase activity (AA) and the effects of T and E2 on aggressive behavior in adulthood de...

Sleep Problems and Aggressive Behavior in Children with ADHD

Objective: Aggression is a disruptive behavior that limits children’s ability for a better adjustment. As commonly reported, sleep problems is associated with the presentation of aggression in ADHD children. In this study, we aimed to investigate the association between sleep problems and aggressive behavior in children with ADHD.  Methods: The study method is correlational and cross-section...

Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

OBJECTIVE Mice with global null mutation of Ceacam1 (Cc1-/-), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blood pressure. Liver-specific rescuing of Ceacam1 reversed all of the metabolic abnormalities in Cc1-/...